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Topics - ukp1997

1
R packages for metabolomics / Difficulties in blank subtraction
While analyzing the LCMS data for untargeted metabolomics, I wanted to do blank subtraction. But when I separately analyze the blank samples and control and then do blank subtraction, it is not working because of the small changes in m/z coming in both the analysis. And when I analyze blank samples together with samples in the same pipeline, I am getting false detections of peaks in the sample.
So how can we efficiently do blank subtraction for untargeted metabolomics?