Skip to main content

Topics

This section allows you to view all Topics made by this member. Note that you can only see Topics made in areas you currently have access to.

Topics - Nhickey

1
Mass spectrometers / Internal Standards for LCMS
From my background reading it is suggested you use internal standards in each LC-MS sample in order to improve the quality of data analysis. However, one of the examples given is of ~8 isotopic compounds such as L-lysine d4 of which many are very expensive and others do not mention what the internal standards are. Is there a minimum number of standards required for a robust experiment or are they specifically dependent on the experiment itself? I currently use pooled QC samples and use reference compounds to calibrate the machine but nothing else.

Any idea/advice would be great,

Niall