I am running GC-MS data, but I have a similar issue. MSDIAL crashes during the alignment step because of no peak information. The weird thing is that not all files have this problem and when I run different times, different files have this problem.
I have not experienced this issue before, but recently yes. I don't know if it is related to the system, since I have updated the systems. I am using the following system:
Processor AMD Ryzen 5 3500U with Radeon Vega Mobile Gfx 2.10 GHz Installed RAM 12.0 GB (9.94 GB usable) System type 64-bit operating system, x64-based processor
Edition Windows 10 Pro Version 21H1 Installed on 10/2/2020 OS build 19043.1706 Experience Windows Feature Experience Pack 120.2212.4170.0
Has anybody ever experienced substantial peak area change after manually curating peak alignment using the "Aligned chromatogram viewer for the simultaneous curation" function?
I just find it weird. For me, after manually curating, all peak areas are about 24 times larger.
Any idea about why this happens? And how to avoid this situation?
Hi Hamza, I developed an R package for this purpose a few months ago, maybe you can give it a try. It is not perfect yet, but I think it can help you. https://github.com/QizhiSu/mspcompiler
Great, I thought .RAW format does not support IMS data. We are using VION with the UNIFI software. However, we cannot convert the IMS containing data into .RAW format. Maybe I can try again. Thanks for your tips.
Hi Max, Are you working with Waters IMS data? I am really interested in how to process Water IMS data with MS-DIAL. Do you acquire your data with the UNIFI software?