Skip to main content


This section allows you to view all Topics made by this member. Note that you can only see Topics made in areas you currently have access to.

Topics - Elena Legrand

Conferences and seminars / EMN Webinar 18th September!
Don't miss it!

Next webinar by Pr Gary Siuzdak "Discovering Metabolites that Alter Physiology, an Omics Perspective"

Click here to register!

Metabolomics and the comprehensive analysis of the metabolome and lipidome has traditionally been pursued with the aim of identifying biomarkers in the diagnosis and prediction of disease. However, the value of metabolomics has been redefined from a simple biomarker identification tool to a technology for the discovery of active drivers of biological processes. It is now clear that the metabolome affects cellular physiology through modulation of other ‘omics’ levels, including the genome, epigenome, transcriptome and proteome. In this presentation, I will focus on our recent progress in using metabolomics to understand how the metabolome influences other omics and, by extension, to reveal the active role of metabolites in physiology and disease. This concept of utilizing metabolomics to perform activity screens to identify biologically active metabolites — which we term activity metabolomics — is already having a broad impact on biology.

Nature Biotechnology 2018, 36 (4), 316-320.
Nature Reviews Molecular Cell Biology 2019 online.

Speaker Details
Gary Siuzdak, Professor and Director of the Center for Metabolomics at The Scripps Research Institute in La Jolla, California ( Gary’s research focuses on developing mass spectrometry-based metabolomic technologies including, XCMS ( and METLIN ( informatic tools, artificial intelligence, metabolomics activity screening and their applications to fundamental biochemistry and therapeutics.
Announcements / Announcement of Opportunity
Applications sought from at least 4 additional early-career scientists to expand the EMN!

Deadline: 31st of July, 2019

We are inviting at least 4 early-career researchers to join the early-career committee of the Society's Early-career Members Network (EMN). The mission of the EMN is to recognize the value and importance of our early-career members, to ensure that their views are heard and acted upon, ultimately improving their experience in metabolomics science and our community. We are looking for creative thinkers to address challenges, such as, how do we help early-career scientists enter and engage with our scientific community? What mechanisms can we construct to allow student contributions (talks and posters) to be openly discussed in a safe environment, where senior scientists can teach and advise, and where no question is too basic? What activities and benefits can we develop to encourage students and postdocs to want to join (and remain members of) the Metabolomics Society even in years when they do not attend the annual conference? What training courses are required? How else can the Society serve its early-career members?

We welcome applications from students conducting higher degrees (Masters, PhDs) in a metabolomics discipline or from those within 5 years of their PhD who are actively engaged in metabolomics science. As an international society we encourage applications from all continents. Successful applicants must be members of the Metabolomics Society (or immediately become members upon joining the committee).

Time Commitment
There is much exciting work to be done and much to achieve! Therefore we anticipate a contribution of up to two hours per week (on average). If the Early-career Members Network organises sessions at conferences or other events, time commitments will increase accordingly. Note also that the existing members of the EMN committee members span many time zones, so some conference calls may occur early or late in the day. No dedicated travel will be required for the EMN committee discussions. The appointment to the EMN committee is for one year initially, and may be extended up to two years. It is your responsibility to discuss this commitment with your supervisor(s) prior to applying.

Application Procedure
Please send the following, in one document (.docx or .pdf), to the EMN committee (

One-page resume with relevant experience in developing and leading networking activities (e.g., student rep for other societies) plus your research experience in metabolomics (e.g., presentations, publications, etc.)
Up to 300 words on why you fit the role and up to an additional 300 words (one page in total) on what ideas you are passionate about developing as part of the Early-career Members Network. Applications will then be reviewed by current members of the EMN committee, and successful candidates will be notified by the end of August 2019 to start in October 2019.
Job opportunities / Postdoctoral position in NMR metabolomics of stem cell differentiation
Postdoc position in NMR metabolomics of stem cell differentiation:

"A Postdoc position is available at the Department of Chemistry and CICECO-Aveiro Institute of Materials, at the University of Aveiro, in Portugal, for an estimated duration of 24 months.


The NMR metabolomics and tissue engineering groups are looking for a highly motivated doctorate researcher to be contracted to work on the development of a bioreactor based on stem cell metabolic markers for the guided production of bone tissue. This work is funded by the Operational Program Competitiveness and Internationalization, in its FEDER/FNR component, and the Portuguese Foundation for Science and Technology (POCI-01-0145-FEDER-028835), through the BIOIMPLANT project on “A Metabolomics-guided Bioreactor for Improved Engineered Bone Implants”.


Our lab combines significant expertise in NMR metabolomics (Professor Ana M. Gil) and in the field of state-of-the-art tissue engineering strategies (Professor Joao Mano). This project pioneers the use of metabolomics to guide stem cell differentiation into osteogenic lineage, to find metabolic biomarkers of differentiation performance. The interdisciplinary nature of the project calls for a candidate ideally with a biochemical orientation and some experience, or at least a strong interest, in NMR methodology.


Potential candidates should hold a doctorate degree in Chemistry, Biochemistry, Biotechnology, Biomedical Engineering or Bioengineering (or related scientific area).


Application procedure

Candidates may find the full description and conditions of the call in or directly through the link The candidate will be led to a University of Aveiro webpage listing the various calls open at present. In this page the candidate should search for 1) “requerimento de candidatura” to find the formal application form and 2) “procedimento para instrução de candidatura” to find general application instructions. Both documents are written in Portuguese and an application form in English can be found at the end of this email. In case you need help with the application procedure, please contact or


The application may be submitted in Portuguese or in English and should be sent by email to the Human Resources Department of the University of Aveiro ( until the 7th of May 2019 (24:00). Please indicate “Application to CDL-CTTRI-108-ARH/2019 call” in the subject line."

Conferences and seminars / EMN Webinar 23/24th April!
Check out the next EMN Webinar!

Session 3 (2019) : Expert Speaker Dr Hiroshi Tsugawa , 40 min presentation followed by 10 min Q/A
23th April 2019 at 23:00 UTC (23:00 GMT, 18:00 EST, April 24th 8:00 Japan time)

Register here!

Computational mass spectrometry in metabolomics to deepen the understanding of metabolisms

Computational mass spectrometry is a growing research field to process mass spectrometry data, assist the interpretation of mass fragmentations, and elucidate unknown structures with metabolome databases and repositories for the global identification of metabolomes in various living organisms. In this talk, Dr Tsugawa will introduce three metabolomics software programs which include (1) MS-DIAL for untargeted metabolomics, (2) MS-FINDER for structure elucidations of unknowns, and (3) MRMPROBS for targeted metabolomics. These programs are demonstrated to perform the comprehensive analyses of primary metabolites, lipids, and plant specialized metabolites where unknown metabolites are also untangled with various methodologies including stable isotope labeled organisms, metabolite class recommendations, and integrated metabolome network analyses. In addition, a computational workflow to link untargeted- and targeted metabolomics is also highlighted in this talk.
Speaker Details Dr Hiroshi Tsugawa got his PhD at Osaka University in Japan, 2012 (in metabolomics for bioengineering) and moved to RIKEN in October 2012. He belongs now to two different laboratories within RIKEN institute: 1) the metabolome informatics research team at RIKEN Center for Sustainable Resource Science and the laboratory for metabolomics in RIKEN Center for Integrative Medical Sciences to learn lipid chemical biology. Dr Tsugawa is developing the tools for computational mass spectrometry for metabolomics, which are distributed at RIKEN PRIMe website (
Conferences and seminars / EMN Webinar 1st March
Don't miss the first webinar of the Early Career Member Network of the Metabolomics Society!

Save the date: this Friday 1st of March. See the ad and registration here
Announcements / EMN Travel Grant 2019: Award Scheme
The Early-career Members Network of the Metabolomics Society Travel Grant 2019: Award Scheme

The Early-career Members Network of the Metabolomics Society Travel Grant aims at providing support to Early-Career scientists* to attend and actively participate in national and international events related to the metabolomics field that will promote their professional development.

Eligible applicants must be:
A member of the Metabolomics Society; and
Within 5 years of obtaining their highest degree.

Up to 4 travel awards for (i) graduate students (master or PhD students) and (ii) post-doctoral researchers will cover travel and accommodation costs and conference fees up to $500. Applicants must be presenting their own metabolomics research and be willing to promote the Metabolomics Society at the event through the use of logos and acknowledgements. Applications will be reviewed by the Early-career Members Network Committee following a pre-established scoring system and the application deadline is February 28th 2019, 12 pm UTC. All entries must be received before the stated deadline in order to be considered. To apply please download the travel award application form. The application form will be accompanied by a short CV of the applicant (max. 2 pages), an abstract of the research project (max. 300 words), a letter of support from the supervisor and a letter of motivation (max. 1 page). By signing this form you agree to the terms and conditions. Send your application to and include the following line in your email subject: “Application: EMN TRAVEL AWARD 2019”. All documents should be submitted in one single pdf file.

Winners will be notified by e-mail by May 2019 and announced on the Metabolomics Society website and in the MetaboNews. Travel awards will be valid through 12 months from the date of announcement. Selected abstract and conference reports will be published in the MetaboNews and/or on the Metabolomics Society website.

Please visit the link to download the application form and for more information:

*All members of the Metabolomics Society that are graduate students (Masters or PhD) or within 5-years post PhD while being in a training position (e.g. post-doc) are considered Early-Career scientists. In certain cases where someone if beyond the 5-year post-PhD limit, exceptions can be made if time off was taken for personal reasons (e.g. family, career break). Any persons with 5-years full-time work experience (or equivalent) after obtaining their PhD shall not be considered an Early Career scientist.
Conferences and seminars / 3rd International Electronic Conference on Metabolomics
Don’t miss the 3rd International Electronic Conference on Metabolomics!

The sciforum is hosting the 3rd International Electronic Conference on Metabolomics, chaired by Pr Peter Meikle, Dr Thusitha W. Rupasinghe, Pr Susan Sumner and Dr Katja Dettmer-Wilde. Check out for interesting presentations on Metabolomics!

When: 15-30 November 2018
Fees: free!