Quick question: if I get an outlier sample, should I rerun all preprocessing steps in xcms (ie. group, retcor etc.)?
I'm using retcor with orbitrap and profstep=0.1 so the process is currently using the outlier sample as a center sample...suffice to say I'm wondering if that means retention time correction has to be repeated?
Thanks!
Depends why it is an outlier. RT shifts or just very different intensities? If the first it could make sense. If not then no I would say. If no shift but unique features pruning those features from the peaktable might be fine.