Title: **coefficient of variation**

Post by:**spapaz** on **May 13, 2020, 05:21:48 AM**

Post by:

Hi Hiroshi,

regarding the coefficient of variation (CV%) shown by the MS-DIAL normalization report.

I have been manually calculating the QCs across samples and QCs, for some internal standards,

but I do not manage to reproduce exactly the same values.

in MS-DIAL, are the CV% calculated based on the log transformed values? (as the report shows the log scale)

I tried both with and without log transforming. When I use the log values, I use the following formula:

= SQRT (10^(LN(10)*STDEV^2)-1)

as discussed here: 10.15406/mojpb.2017.06.00200

I attach the CV% calculated on the log values (for QCs and Samples), and the corresponding ones from MS-DIAL (in red)

(Note: they are not expressed as %, but as fraction, i.e. CV 0.15 = 15%)

Thank you!

Stefano

regarding the coefficient of variation (CV%) shown by the MS-DIAL normalization report.

I have been manually calculating the QCs across samples and QCs, for some internal standards,

but I do not manage to reproduce exactly the same values.

in MS-DIAL, are the CV% calculated based on the log transformed values? (as the report shows the log scale)

I tried both with and without log transforming. When I use the log values, I use the following formula:

= SQRT (10^(LN(10)*STDEV^2)-1)

as discussed here: 10.15406/mojpb.2017.06.00200

I attach the CV% calculated on the log values (for QCs and Samples), and the corresponding ones from MS-DIAL (in red)

(Note: they are not expressed as %, but as fraction, i.e. CV 0.15 = 15%)

Thank you!

Stefano

Title: **Re: coefficient of variation**

Post by:**Hiroshi Tsugawa** on **May 13, 2020, 07:43:25 PM**

Post by:

Thanks Stefano,

the CV value is simply calculated by the original, i.e. non-transformed values although the Y-scale is finally visualized by log-transformed value. I will prepare both CV values into the figure at next update.

Thanks,

Hiroshi

the CV value is simply calculated by the original, i.e. non-transformed values although the Y-scale is finally visualized by log-transformed value. I will prepare both CV values into the figure at next update.

Thanks,

Hiroshi