Hello,
I'm currently working on a Waters Synapt (ESI + source) and I encounter an important loss of sensitivity over time, probably due to the source clogging (I'm working with intact proteins).
Which normalisation method would you recommend to fix this quasilinear "drift" ? Could we assume that this drift is similar to a dilution effect and correct it using PQN or Median normalisation ?
Thanks for your help.