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Topic: LC/MS blank removal from samples (Read 97 times) previous topic - next topic

  • joshb
  • [*]
LC/MS blank removal from samples
Hi all,

I'm doing an untargeted metabolomics project to find new bioactive Streptomyces compounds.  I'd like to subtract the media blanks from my samples, leaving the in theory only the produced metabolites showing in my chromatograms and spectra.  The vendor software (Waters) does have a function for this, but it's manual so obviously takes quite a bit of time.

Can anyone recommend any free software that can do this automatically?  I've tried XCMS Online and MZmine but haven't been able to find an appropriate setting (it's entirely possible I've missed it though, so please say if I have!).  I know it's possible to generate peak lists and just subtract the blank, but that doesn't give chromatograms/spectra.

Thanks,

Josh
  • NCIMB & Robert Gordon Uni