Buffering both Eluents - Acetonitrile with Ammonium Carbonate January 08, 2019, 04:16:17 AM Good morning fellow Metabolomicians!We observe a Retention Time drift but a minor one. And now, while I am in the middle of optimizing, I am thinking:Would it be better to change the apolar eluent from pure AcN to AcN with 5% water containing 10mM Ammonium Carbonate?Thanks in advance for your effort to help to newbee! Greetings from Germany!DebbieP.S.: HILIC mode! Polar eluent: 10mM Ammonium Carbonate in water.