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Topic: Retention time correction (Read 58 times) previous topic - next topic

Retention time correction

Hello,

I'm supposed to analyze my LC-Orbitrap data on XCMS, however I'm observing a retention time shift on my chromatogram.

The standard error is about 1% for a specific range in my chromatogram, and I observe about half a minute of retention time shift in a 40 minute run.

I was wondering, can XCMS successfully correct such big retention time shifts? Is there a specific standard deviation for XCMS's retention time correction?