QC correction in Compound Discoverer (ThermoFisher)

March 30, 2020, 10:47:54 AM

Hello,

ThermoFisher's compound discoverer provides two different methods of correcting for drift using either linear or cubic spline regression.

I'm not too well versed in statistics and was wondering if someone could help me understand how this is done (especially cubic spline).

For example, what would be my coefficients (beta's) if I was using linear regression to correct for drift?

Thank you.