Skip to main content
Topic: Pos/Neg Switching on Orbitrap (Read 343 times) previous topic - next topic

Pos/Neg Switching on Orbitrap

I am running a pos/neg switching LC-MS only method on the orbitrap.  Is it possible to handle such files in MS-DIAL?  Any trick - if I specify positive and then negative will it extract on the + and - methods (I hope)?  Any helps - including if this impossible - would be great.


Re: Pos/Neg Switching on Orbitrap

Reply #1

We work in such a manner and i found no problems processing my raw files in MS-DIAL. Once that you select the polarity mode then it goes in that way and then you can continue with the other polarity mode. Just be careful to be very clear with your naming both in projects and alignments.