Long processing time issue with Waters data November 17, 2021, 10:39:15 AM I am processing waters .RAW data acquired on a Synapt G2-Si with the ABF converter and then through MSDIAL. Unfortunately I have had trouble getting reasonable processing times. The acquisition is an 11 minute positive mode MSE/DIA method, the RAW and ABF files are ~5 gb unfortunately which I think is part of the issue. I have 105 files which I have tried processing with different numbers of threads. With two threads 25-40 GB RAM are used. With any large number of files (~30) MS-DIAL will frequently crash before completion. If more than one adduct is selected this problem is greatly exacerbated.Does anyone have suggestions on how to ease the computational load or solve this problem?