Thoughts on types of anti-coagulant used in blood plasma August 03, 2012, 02:01:27 PM Hi friends,Working on a baseline study at the time compaing metabolites in different types of samples such as serum, urine, plasma, and feces. Does anyone have suggestions on literature or preference as far as anti-coagulants effecting the results of metabolite concentrations. At the time being EDTA is looking like the more prominent source however in the clinical setting lithium heparin is used also sodium heparin. What are y'alls experiences in that regard.Also is it almost a complete waste to run plasma for comparison reasons. It seems to me like while it is reproducible, the background noise is high and the concentration compared to serum is much lower almost losing out on roughly 20 metabolites in a GC/MS platform.Any thoughts would be greatly appreciated.