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Topic: Combining DDA and DIA  (Read 1997 times) previous topic - next topic

Combining DDA and DIA

Dear Hiroshi and dear MS-DIAL team,

I plan to combine DDA and DIA for some future experiments (e.g., DDA for pooled QCs, DIA/SWATH for samples) and I was thinking about a workflow similar to R-based DaDIA approach (10.1021/acs.analchem.0c05022).
I really like the software, so I wanted to ask if it's possible to align DDA and DIA data in MS-DIAL?
As far as I understand it, it's only possible to decide batchwise if data is processed as DDA or DIA and it's not possible to align both data types in a straightforward manner.
Do you plan to implement the possibility to analyze mixed batches of DDA and DIA data in future releases, e.g., by selecting datatype for each file in the sample list and align DDA and DIA files in the end?

Thanks a lot for your great work and best regards,
Max