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Topic: Missing values in Lowess/Spline normalization method (Read 223 times) previous topic - next topic

Missing values in Lowess/Spline normalization method

Hello everyone,

How should missing values have to be represented before using LOWESS/Spline normalization software? They should be represented with zeros "0", "NA", or only blank cells.

Or do you recommended firstly doing missing values imputation and then doing LOWESS/Spline normalization for batch/signal correction?

Thank you in advance for your answers.