CHEBI hierarchy

July 02, 2023, 03:57:05 PM

Hi, I'm trying to apply this very cool pathway analysis to my lipidomics data.
https://pubmed.ncbi.nlm.nih.gov/36376837/

My problem is that CHEBI IDs for lipids are difficult to find in databases as the ones used in the Reactome pathways are often high-level generalised ones. Eg. https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:17815 is a generic 1,2-diglyceride. When I search for matches in Reactome for my diglyceride annotations, they don't match as they are for specific DG species. Is there a hierarchical system by which I can find matches for my specific annotations, as well as any entries in CHEBI for higher ontological classes?

To complicate matters further, there is a separate entry for a diglcyeride with unspecified positions https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI%3A18035, and a third for diradylglycerides with unspecified r-groups that may be acyl, https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI%3A76578.