How to adjust minimum peak height during data processing in MS-DIAL v. 4.80

February 12, 2024, 10:42:41 AM

Hello everyone,
I have general but very important and basic question. I would like to ask you how you setting up "minimum peak height" parameter in peak detection settings before data processing in MS-DIAL v.4.8? How you setting up the treshold? Do you respect blank sample intensity? I worry about integration some noise artefacts, but don't want to lost some low intensity diagnostic metabolites. I do untargeted metabolomics fingeprinting methods with LC/-MS. My blank intensity is 6.0e6 and data were measured on tTOF Sciex 6600 system. Could you recommend which "minimum peak height" set?

Thanks a lot!
Adam