CAMERA for peptide isotopic distributions? October 11, 2014, 09:37:33 AM Has anyone successfully used CAMERA for peptide MS data? Peptides have different isotopic distributions from metabolizes, due mostly (I believe) to their generally larger masses and higher charge states. I tried CAMERA with default settings on xcms centWave-picked peaks, hoping to get isotopic clusters annotated. But the annotations were mostly 1+, with a smaller number of 2+ Isotopes (perhaps a few 3+). Whereas my peptides run up to 5+, with the majority of them 2+ and 3+.First, can this be done? And if so, is it done by modifying the isotopeMatrix? From earlier postings, it appears this only handles one charge state. Do I construct multiple matrices, one per charge state?Thank you,- PeterP.S. This is related to my recent question on the xcms forum, where Jan suggested using CAMERA.