Do intensity drifting accross samples influence CAMERA January 13, 2016, 07:08:47 AM Hello everyone,I am currently using CAMERA function for metabolite annotation. I know that CAMERA is directly working on the XCMS object and do the annotation based on the peaks after XCMS fillingpeaks. By calculating correlations within one sample and accross samples for peak grouping. But this correlation is done based on the peak intensity. In our case, we know that we have signal intensity drift within one analytical batch(220 samples) and even more serious intensity drifting between batches (8 batches). So I am worried that the correlation function cannot work well to group peak together. Do I misunderstand the CAMERA ? Any suggestions?Thanks a lot in advance and I am eager to hear ideas from you.