Re: Do intensity drifting accross samples influence CAMERA
Reply #1 –
The intensities of ions originating from the same molecule should "drift" in the same way and therefore the answer is no.
If you changed something within your analysis that can affect the ratio of fragments then the answer is yes. I have seem routine maintenance done by the vendor's technician change the fragment ratios (never figured what was changed) so avoid this kind of thing.
I have seen cases where adduct/polymer formation have non-linear behavior and in those cases the correlation can suffer.
I don't recall seeing it but I imagine detector saturation can also cause non-linear behavior.