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Messages - Ken Chalcraft

1
Mass Spectrometry Interest Group / Best instrument for LC-MS metabolomics?
If robustness is your primary concern, I would recommend a UPLC system over nanoLC although I will admit the gap between the two seems to be quickly narrowing. I have had very good experiences with Waters Acquity and Agilent 1200 and 1290 UPLC in particular in terms of their reliability. 

For what its worth, I have had much better luck with QTOF (Agilent and Bruker) compared to Orbitrap in terms of reliability and maintenance.