Are MS files generated in append-only fashion? April 04, 2014, 06:25:18 AM I asked the following question on the ProteoWizard's msconvert forum, and they (Parag Mallick, the top engineer) said that the XCMS engineers were working on it and I should ask them:===============QuoteWould anyone know if the main MS vendors (Thermo, Ab-Sciex, Agilent, Waters -- in that order) create their MS raw files as "append-only"? That is, the data always gets appended to the end as these files get generated by the MS? If they're not 100% append, are they mainly append, at least while the MS is generating the file?========= Quote Selected